Opus Brightening & Renewal Cream

• For external use only. Avoid eyes, eyelids, lips, and mucous membranes.
• Photosensitivity: Tretinoin increases sun sensitivity — daily SPF 30+ required.
• Early use may cause dryness, peeling, redness, or stinging.
• Pregnancy: Do not use during pregnancy or if attempting to conceive.
• Stop and seek clinical advice for severe irritation, blistering, swelling, or rash.

• Apply a pea-sized amount to clean, fully dry skin at night.
• Start 2–3 nights/week, increase as tolerated.
• Avoid eyes, corners of nose/mouth, and broken skin.
• If sensitive, use the “sandwich method”: moisturizer → cream → moisturizer.
• Use broad-spectrum SPF every morning.

• Other retinoids (adapalene, tazarotene) unless directed by clinician.
• Layering with benzoyl peroxide at same time (separate AM/PM).
• High-strength acids (AHA/BHA/peels) or harsh scrubs on same night.
• Waxing, laser, dermabrasion on treated areas until irritation resolves.
• Excessive sun or tanning beds.

• Local: dryness, flaking, mild burning, tingling, redness.
• Adjustment period: temporary “purging” (breakouts) as cell turnover increases.

Most reactions improve with dose reduction or slower frequency. If persistent or severe, stop and contact your clinician.

• Severe redness, blistering, open sores, swelling, or intense burning.
• Worsening dark patches from irritation (post-inflammatory hyperpigmentation).
• Signs of allergic reaction: facial swelling, hives, trouble breathing — seek emergency care.

• Pregnancy or planning pregnancy (tretinoin-containing products).
• Hypersensitivity to any listed ingredients.
• Application on broken, eczema-affected, or sunburned skin.

• Benzoyl peroxide: can inactivate tretinoin — separate AM/PM.
• Strong acids/peels: may increase irritation if combined.
• Vitamin C: if stinging occurs with tretinoin, move Vit C to mornings or alternate nights.
• If recently used oral isotretinoin, ask your clinician before starting.

• Do not use during pregnancy.
• If breastfeeding, avoid applying on or near chest; consult clinician.

• Skin for irritation or worsening pigmentation.
• Consider slower frequency if dryness or peeling persists.
• Stop and reassess if no improvement after 8–12 weeks.

• Store at 20–25°C (68–77°F).
• Protect from heat and light; keep cap tightly closed.
• Keep out of reach of children.

• Ascorbic Acid 10%
• Resorcinol 0.1%
• Tretinoin 0.01%
• Vitamin E Acetate 5%