This triphasic combination pill contains norgestimate (a progestin) and a gentle 0.025 mg dose of ethinyl estradiol. Instead of delivering the same hormone level every day, it shifts in three phases to more closely mimic the body’s natural cycle. For many users, that means steady mood, fewer hormone swings, predictable periods, and reliable pregnancy protection when taken as directed. It’s often chosen for lighter menstrual bleeding, improved cramping, and acne-support benefits due to norgestimate’s lower androgenic activity. A trusted option for those wanting effective contraception with a softer hormonal footprint.
Norgestimate 0.18 mg, 0.215 mg, 0.25 mg | ethinyl estradiol 0.025 mg (Tri-Lo Estarylla, Tri-Lo-Marzia, Tri-Lo-Sprintec)
From: $25.00/month
Effective contraception with a softer hormonal footprint.
This triphasic combination pill contains norgestimate (a progestin) and a gentle 0.025 mg dose of ethinyl estradiol. Instead of delivering the same hormone level every day, it shifts in three phases to more closely mimic the body’s natural cycle. For many users, that means steady mood, fewer hormone swings, predictable periods, and reliable pregnancy protection when taken as directed. It’s often chosen for lighter menstrual bleeding, improved cramping, and acne-support benefits due to norgestimate’s lower androgenic activity. A trusted option for those wanting effective contraception with a softer hormonal footprint.
⚠️ Safety Information
Use this medication exactly as prescribed. Click below to expand each section.
🛑 Boxed Warning: Smoking & Blood Clots
- Combined hormonal pills increase the risk of serious cardiovascular events such as blood clots, stroke, or heart attack.
- This risk increases with age, smoking, high blood pressure, obesity, and certain medical conditions.
- Do NOT use if you smoke and are age 35 or older.
🚫 Do NOT Use If
- You have a history of blood clots (DVT, PE), stroke, or heart attack.
- You have certain migraines (especially migraine with aura or new migraines after starting birth control).
- You have uncontrolled high blood pressure.
- You have breast cancer or estrogen/progestin-sensitive tumors.
- You have active liver disease or liver tumors.
- You are pregnant.
📋 Tell Your Clinician Before Starting
- If you smoke—especially over age 35.
- If you have diabetes, high cholesterol, hypertension, or a family history of blood clots.
- If you have gallbladder disease, kidney problems, thyroid disorders, or depression.
- About all medications and supplements, including herbal products.
💊 How to Take
- Take 1 pill daily at the same time every day.
- If you miss pills, follow the instructions in your pack and use backup contraception if needed.
- Vomiting or severe diarrhea may lower effectiveness — call your clinician if unsure.
🙂 Common, Temporary Side Effects
- Nausea, bloating, breast tenderness.
- Headache, mood changes, or mild acne changes.
- Breakthrough bleeding or spotting during the first few packs.
⚠️ Rare but Serious Risks
- Blood clots in the legs or lungs.
- Stroke or heart attack.
- Liver problems or gallbladder issues.
- Severe high blood pressure.
Seek medical care right away for chest pain, sudden shortness of breath, coughing up blood, leg swelling, vision changes, or severe headaches.
🚫 What to Avoid
- Smoking — especially age 35 and older.
- Certain seizure or tubercolosis medications, rifampin, and St. John’s Wort.
- Skipping pills or taking them at inconsistent times — may reduce effectiveness.
🔁 Drug Interactions
- Some seizure medicines (carbamazepine, phenytoin, topiramate).
- Rifampin and some HIV medications.
- St. John’s Wort — may lower hormone levels and cause breakthrough bleeding or pregnancy.
⛔ Stop and Seek Help If
- Chest pain, trouble breathing, coughing blood.
- Severe headache or new migraines.
- Sudden numbness or weakness on one side of the body.
- Severe leg pain/swelling.
- Vision changes or loss of vision.
- Yellowing of the skin or eyes (liver problems).
📦 Storage
- Store at room temperature away from moisture and heat.
- Keep in original packaging until use.
- Keep away from children and pets.
❔ Frequently Asked Questions
💡 How does this pill prevent pregnancy?
It prevents ovulation, thickens cervical mucus to block sperm, and thins the uterine lining to reduce chance of implantation.
⌛ How long until it works?
If taken on Day 1 of your period, protection is immediate. If started any other day, use back-up contraception for 7 days.
🤕 Will it make my period more comfortable?
Many users experience less cramping, lighter flow, and more predictable cycles after a few months.
🙂 Can this help with acne?
Norgestimate has lower androgen effects and may improve hormone-related acne for some people.
📅 What if I miss a pill?
Take it as soon as possible, continue the pack, and use back-up if recommended. Multiple missed pills may require emergency contraception depending on timing.
💊 What if I miss two or more pills?
Follow the instructions in your pill pack and use backup contraception. If you had unprotected sex, ask your clinician whether emergency contraception is recommended.
😧 Is breakthrough bleeding normal?
Yes — spotting is common during the first 2–3 packs as your body adjusts. It usually improves over time.
🧪 Can I take it with other medications?
Some medications and herbal supplements can lower effectiveness. Always tell your clinician about everything you take.
🚫 Who should NOT take this pill?
People with clotting disorders, certain migraines, breast cancer, severe liver disease, or smokers 35+ should avoid combined hormonal pills.
👩⚕️ What if I get a severe headache or vision changes?
Stop the pill and seek medical care — this could indicate a rare but serious side effect.
💗 Can I use this while breastfeeding?
Combined pills may decrease milk supply. Progestin-only pills are usually preferred for early breastfeeding. Ask your clinician about safer options.
🔄 I want to switch from another pill — how?
In most cases, you can start the new pill immediately after finishing the active pills from your old pack. Ask your provider for exact steps.
📉 Will it affect my fertility long-term?
No. Fertility typically returns quickly after stopping, usually within 1–3 menstrual cycles.
🛑 When should I seek urgent care?
Severe chest pain, sudden trouble breathing, coughing blood, severe leg pain/swelling, yellowing skin/eyes, or sudden severe headaches.
Related products
-
Select options This product has multiple variants. The options may be chosen on the product pageRx
Levonorgestrel 0.15 mg / Ethinyl estradiol 0.03 mg / Ethinyl estradiol 0.01 mg (Amethia,Camrese, Daysee, Jaimiess, Simpesse)
Designed to prevent pregnancy while helping maintain natural-feeling cycle. balanced and lighter, more predictable periods.
From: $25.00/monthSelect options This product has multiple variants. The options may be chosen on the product page
-
Select options This product has multiple variants. The options may be chosen on the product pageRx
Levonorgestrel 0.1 mg | Ethinyl estradiol 0.02 mg (Lutera, Vienva, Aubra, Aviane, Larissia, Falmina, Delyla)
Low-dose, once-daily birth control designed for reliable pregnancy prevention and smoother cycles.
From: $25.00/monthSelect options This product has multiple variants. The options may be chosen on the product page
- Select options This product has multiple variants. The options may be chosen on the product page
-
Select options This product has multiple variants. The options may be chosen on the product pageRx
Norgestimate 0.18mg, 0.215mg, 0.25mg | Ethinyl estradiol 0.035 mg (Tri-Femynor, Tri-Previfem, Tri-Sprintec)
Natural-feeling hormone shifts with reliable protection, predictable cycles, and acne benefits.
From: $25.00/monthSelect options This product has multiple variants. The options may be chosen on the product page
Reviews
There are no reviews yet.