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Erythromycin 2% Gel (60g)

Prescription Required

From: $65.00/month

A lightweight antibiotic gel that targets acne-causing bacteria to reduce breakouts, calm inflammation, and help keep skin clear and balanced.

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A topical prescription antibiotic designed to treat acne by reducing the bacteria that contribute to whiteheads, blackheads, and inflamed pimples. It helps calm redness, decrease swelling, and prevent new breakouts when used consistently. Because it’s gentle and non-comedogenic, it’s a good choice for people with sensitive or easily-irritated skin. Often used alone for milder acne—but even more effective when paired with ingredients like benzoyl peroxide or topical retinoids—erythromycin 2% fits well into a long-term, dermatologist-approved acne routine.
A topical prescription antibiotic designed to treat acne by reducing the bacteria that contribute to whiteheads, blackheads, and inflamed pimples. It helps calm redness, decrease swelling, and prevent new breakouts when used consistently. Because it’s gentle and non-comedogenic, it’s a good choice for people with sensitive or easily-irritated skin. Often used alone for milder acne—but even more effective when paired with ingredients like benzoyl peroxide or topical retinoids—erythromycin 2% fits well into a long-term, dermatologist-approved acne routine.

⚠️ Safety Information

⚠️ Serious Warnings / Precautions
  • For external use only. Do not use in eyes, mouth, or vagina.
  • Stop use and contact a clinician if you develop severe redness, burning, swelling, crusting, or oozing.
  • Rare allergic reactions may occur. Seek urgent care if you develop hives, shortness of breath, or facial swelling.
  • Do not apply to broken, sunburned, overly dry, or irritated skin.
  • Avoid simultaneous use of other irritating topical products unless approved by your clinician.
🚫 Who Should NOT Use
  • Individuals with known allergies to erythromycin or other macrolide antibiotics.
  • People who have had severe reactions to topical antibiotics before.
  • Do not use on large damaged areas of skin unless directly instructed by a clinician.
  • Pregnant or breastfeeding individuals should consult their clinician before use.
💊 How to Use
  • Apply a thin layer to clean, dry skin once or twice daily as directed.
  • Avoid applying immediately after using harsh cleansers, scrubs, or alcohol-based products.
  • Wash hands after application.
  • Consistent daily use is key to effectiveness; do not spot-treat only.
🛑 Drug Interactions
  • Be cautious when combining with other acne medications like benzoyl peroxide, tretinoin, or salicylic acid — irritation may increase.
  • Avoid using other topical antibiotics (e.g., clindamycin) unless instructed.
  • Tell your clinician about all prescription and OTC products you use on your skin.
💢 Common Side Effects
  • Mild dryness or peeling
  • Redness or warmth at application site
  • Mild burning or stinging
  • Temporary increase in irritation at the start of treatment
⚡ Serious Side Effects (Seek medical help)
  • Severe rash or blistering
  • Swelling of lips, face, or throat
  • Severe itching or widespread skin reaction
📦 Storage
  • Store at room temperature (68–77°F / 20–25°C).
  • Keep away from heat and direct sunlight.
  • Keep cap tightly closed when not in use.
  • Keep out of reach of children and pets.

Disclaimer: This information is for educational display and does not replace professional medical advice. Follow your prescriber’s instructions.

❓ Frequently Asked Questions (FAQ)

⏱️ How long does it take to start working?

Most users see early improvement around weeks 4–6, with the full benefit taking 8–12 weeks. Consistent daily use is important.

🤝 Can I combine it with benzoyl peroxide?

Yes — this is a common combination. Benzoyl peroxide helps reduce antibiotic resistance and boosts acne-clearing power. Your clinician will guide how to layer them.

🌙 Should I apply it once or twice per day?

Your prescriber will decide based on your skin. Many start with once daily and increase to twice daily if tolerated and if breakouts are more stubborn.

🔥 Why does it sting when I apply it?

A mild burning or tingling sensation is common when first starting. This typically improves within a few days as your skin adjusts.

🙅‍♂️ Can using erythromycin cause antibiotic resistance?

It can. This is why clinicians often pair it with benzoyl peroxide. Using it alone long-term increases the risk of bacteria becoming resistant.

🧴 Can I use a moisturizer with it?

Yes! A gentle, non-comedogenic moisturizer can help reduce dryness or irritation. Apply moisturizer after the medication unless your clinician advises otherwise.

💄 Can I apply makeup over it?

Yes — as long as the gel has fully dried. Use non-comedogenic makeup to avoid clogging pores.

😬 Will my skin purge when I start?

Purging is more common with retinoids than antibiotics. Most people do NOT purge on erythromycin, but a brief flare in irritation or small bumps can occur.

🧘 Is erythromycin good for sensitive skin?

Generally yes. It’s considered gentler than many other acne treatments and is often well-tolerated even by sensitive or reactive skin types.

🎯 Can I use it as a spot treatment?

You can, but it works better when applied as a thin layer over all acne-prone areas to prevent new breakouts.

📌 Should I apply it before or after moisturizer?

Most clinicians recommend applying erythromycin on clean, dry skin first. If your skin is very sensitive, you can apply moisturizer first to buffer irritation (“moisturizer sandwich”).

✨ Can I use it with tretinoin?

Yes — many acne routines combine an antibiotic in the morning with tretinoin at night. This provides both antibacterial and pore-unclogging benefits.

🤰 Is it safe during pregnancy?

Topical erythromycin is often considered low-risk, but you must confirm with your clinician before using it during pregnancy or breastfeeding.

👦 Can teens use erythromycin gel?

Yes. It is commonly prescribed for adolescent acne and is generally well tolerated.

🫧 How much should I apply?

Apply a thin, even layer over the entire affected area. Using more will not clear acne faster and may increase irritation.

🌅 Is it better in the morning or at night?

It can be used either time. Many routines apply erythromycin in the morning and a retinoid at night.

⛔ What happens if I stop using it suddenly?

Acne may gradually return if the underlying causes persist. Antibiotic-based treatments should be used for the minimum effective duration and reassessed by a clinician.

📦 How should I store it?

Store at room temperature and keep the cap tightly closed. Do not freeze. Keep away from heat and direct sunlight.

🌤️ Does erythromycin make me more sensitive to the sun?

It is not strongly photosensitizing, but irritated skin can be more reactive. Daily sunscreen is still recommended for all acne routines.

Additional information

Billing Cycle

Monthly, Quarterly, Semi-annual, Annual

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